Every GLP-1 Medication, Compared
Complete 2026 comparison chart
A side-by-side comparison of every major FDA-approved GLP-1 medication based on published clinical trial data and FDA labels. This is informational only — consult your healthcare provider before making any medication decisions.
About This Comparison
All data below comes from FDA-approved labels and published clinical trial results. Clinical trials had different designs, patient populations, and durations — results across different trials cannot be directly compared. Weight loss percentages reflect trial averages; individual results vary significantly. This is not a recommendation for any medication. Only your healthcare provider can determine which medication is appropriate for you.
Complete Comparison Chart
Every major FDA-approved GLP-1 medication at a glance.
Scroll horizontally to view all medications.
Individual Medication Details
Semaglutide vs Tirzepatide
The two main active ingredients in today's GLP-1 landscape work differently. Semaglutide targets GLP-1 receptors only, while tirzepatide is a dual-agonist targeting both GLP-1 and GIP receptors. Clinical trials have shown different average weight loss outcomes, though direct comparison across trials is unreliable.
Read full comparisonOral vs Injectable
Most GLP-1 medications are weekly injections, but oral options are expanding. The Wegovy pill and Rybelsus are currently available in oral form, with orforglipron (Eli Lilly) under FDA review. Each formulation has distinct practical trade-offs in terms of convenience, dosing, and clinical data maturity.
Read full comparisonDetailed Comparisons
Dive deeper into specific medication matchups.
Ozempic vs Wegovy
Same semaglutide, different approvals
Read comparisonOzempic vs Mounjaro
Semaglutide vs tirzepatide for diabetes
Read comparisonWegovy vs Zepbound
Top weight loss medications compared
Read comparisonMounjaro vs Zepbound
Same tirzepatide, different approvals
Read comparisonWegovy Pill vs Injection
Oral vs injectable semaglutide
Read comparisonBrand vs Compounded
FDA-approved vs compounded GLP-1
Read comparisonImportant Note About This Data
This table presents published data from FDA labels and clinical trials. Clinical trials for each medication had different designs, patient populations, inclusion criteria, and durations — results across different trials cannot be directly compared. Weight loss percentages are trial averages; individual results vary significantly. Pricing reflects approximate list prices and does not account for insurance, savings programs, or pharmacy discounts. Only your healthcare provider can determine which medication is appropriate for you.
Medical Disclaimer: This content is for informational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always consult your healthcare provider before making any decisions about your health or medications.
Frequently Asked Questions
Common questions about GLP-1 medications.
Which GLP-1 medication is most effective for weight loss?
Clinical trials have shown varying levels of weight loss across different GLP-1 medications. Tirzepatide (Zepbound) showed approximately 20.9% average weight loss in SURMOUNT-1, while semaglutide (Wegovy injection) showed approximately 14.9% in STEP 1. However, these were separate trials with different populations and cannot be directly compared. Individual responses vary significantly, and your healthcare provider can help determine which option is appropriate for you.
What is the newest GLP-1 medication?
As of early 2026, the most recent GLP-1 approvals include the Wegovy pill (oral semaglutide 25mg, approved December 2025) and Wegovy HD (semaglutide 7.2mg injection, approved March 2026). Eli Lilly's orforglipron, an oral non-peptide GLP-1, is currently under FDA review.
Are all GLP-1 medications injections?
No. While most GLP-1 medications are injections, oral options exist. Rybelsus (oral semaglutide) is approved for type 2 diabetes, and the Wegovy pill (oral semaglutide 25mg) is approved for weight management. Eli Lilly's orforglipron, another oral option, is under FDA review. The trend is toward more oral options becoming available.
Which GLP-1 medication is the cheapest?
The Wegovy pill launched with a starting price around $149/month through manufacturer savings offers, making it the most affordable branded option at list price. However, actual out-of-pocket costs depend on insurance coverage, pharmacy, and available savings programs. Some medications may be better covered by certain insurance plans.
Does Dose AI track all of these medications?
Yes. Dose AI tracks any GLP-1 medication regardless of brand or formulation. Whether you take Ozempic, Wegovy, Mounjaro, Zepbound, or any other GLP-1, the app helps you log doses, track symptoms, monitor weight changes, and manage your nutrition.
Track Any GLP-1 Medication
No matter which GLP-1 you're on, Dose AI tracks your doses, symptoms, weight, and nutrition in one place.
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